Palladium‐Catalyzed Oxidation of Glucose in Glycopeptides**

Selective modification of carbohydrate residues in glycopeptides is highly relevant as a tool glycobiology. In particular, oxidation allows for subsequent ligation with label or handle and can be effectuated enzymatically chemically. Chemical nearly invariably done using periodate cleavage, leading to aldehydes. this work, we applied palladium-catalyzed the same purpose. The catalyst, [(neocuproine)PdOAc]2OTf2, developed site-selective mono- oligosaccharides on preparative scale, proved suitable glucose series glucopeptides. Careful optimization reaction conditions necessary get acceptable conversions without excessive over-oxidation amino acid side-chains, particular threonine. resulting carbonyl function used an oxime-ligation biotin. A protocol analysis products mass spectrometry also reported.